For an oocyte being All set for fertilization and progress into an embryo, the right list of genes has to be turned on. Namekawa suspected this pre-programming with the oocyte genome occurs in various levels — the very first a single commencing round the time a woman is born. He thought that chromatin remodeling proteins did much of the do the job, by shifting spools all-around.
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Namekawa believes that in human oocytes, changes in these styles could disrupt the delicate choreography of genes being turned on and off at the appropriate situations — leaving them unprepared for fertilization or progress into wholesome embryos. Variations in chromatin framework as an oocyte ages may additionally influence just how that chromosomes segregate for the duration of cell division.
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